Help with Protein

Coevolutionary signals across protein lineages help capture multiple protein conformations.

A long-standing problem in molecular biology is the determination of a complete functional conformational landscape of proteins. This includes not only proteins' native structures, but also all their respective functional states, including functionally important intermediates. Here, we reveal a signature of functionally important states in several protein families, using direct coupling analysi...

Learning Languages with Help

Grammatical inference consists in learning formal grammars for unknown languages when given learning data. Classically this data is raw: strings that belong to the language or that do not. We present in this paper the possibility of learning when presented with additional information such as the knowledge that the hidden language belongs to some known language, or that the strings are typed, or...

I-15: Assessment of Transcript and Protein Profiles of Infertile Individual May Help to Select Individuals with Low Fertilization Potential Candidate of Artificial Oocyte Activation

Background Following sperm penetration, oocyte is activated by sperm oocyte activating factors (SOAFs) released by sperm. Spermspecific phospholipase C isoform ζ (PLCζ) and post acrosomal WW binding protein (PAWP) are two nominees for the SOAF. PLCζ is located back-to-back with another testis-specific gene called CAPZA3. These two genes share a common bidirectional promoter. In this study we as...

Help with Dignity

"Help" with HELLP syndrome.

Pregnancy-induced hypertension (PIH), also known as preeclampsia, remains one of the leading causes of maternal death worldwide. The term PIH describes the development of hypertension with proteinuria and/or pathological edema after the twentieth week of gestation. Parturients with PIH usually have multiple organ alterations (Table 1). Although the etiology of PIH is unknown, it appears obvious...